Rosenthal, R;
Swanton, C;
McGranahan, N;
(2021)
Understanding the impact of immune-mediated selection on lung cancer evolution.
British Journal of Cancer
, 124
(10)
pp. 1615-1617.
10.1038/s41416-020-01232-6.
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Abstract
Summary Understanding how a tumour evolves and avoids immune recognition is paramount to improving cancer immunotherapy and patient outcome. Here we examine our recent integration of multi-region genomic, transcriptomic, epigenomic, pathology, and clinical data, highlight the need for a systematic examination of immune escape mechanisms, and discuss implications for immunotherapy approaches.
| Type: | Article |
|---|---|
| Title: | Understanding the impact of immune-mediated selection on lung cancer evolution |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/s41416-020-01232-6 |
| Publisher version: | https://doi.org/10.1038/s41416-020-01232-6 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Oncology, Cancer genomics, Cancer microenvironment, Non-small-cell lung cancer |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10132894 |
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