De Andrade, MO;
Haqshenas, SR;
Pahk, KJ;
Saffari, N;
(2021)
Modelling the Physics of Bubble Nucleation in Histotripsy.
IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
, 68
(9)
pp. 2871-2883.
10.1109/TUFFC.2021.3097118.
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Abstract
This work aims to establish a theoretical framework for the modeling of bubble nucleation in histotripsy. A phenomenological version of the classical nucleation theory was parametrized with histotripsy experimental data, fitting a temperature-dependent activity factor that harmonizes theoretical predictions and experimental data for bubble nucleation at both high and low temperatures. Simulations of histotripsy pressure and temperature fields are then used in order to understand spatial and temporal properties of bubble nucleation at varying sonication conditions. This modeling framework offers a thermodynamic understanding on the role of the ultrasound frequency, waveforms, peak focal pressures, and duty cycle on patterns of ultrasound-induced bubble nucleation. It was found that at temperatures lower than 50 °C, nucleation rates are more appreciable at very large negative pressures such as -30 MPa. For focal peak-negative pressures of -15 MPa, characteristic of boiling histotripsy, nucleation rates grow by 20 orders of magnitude in the temperature interval 60 °C-100 °C.
| Type: | Article |
|---|---|
| Title: | Modelling the Physics of Bubble Nucleation in Histotripsy |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1109/TUFFC.2021.3097118 |
| Publisher version: | https://doi.org/10.1109/TUFFC.2021.3097118 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Bubble nucleation, classical nucleation theory, histotripsy |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Chemical Engineering UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10132937 |
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