Fiard, G;
Stavrinides, V;
Chambers, ES;
Heavey, S;
Freeman, A;
Ball, R;
Akbar, AN;
(2021)
Cellular senescence as a possible link between prostate diseases of the ageing male.
Nature Reviews Urology
, 18
pp. 597-610.
10.1038/s41585-021-00496-8.
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Abstract
Senescent cells accumulate with age in all tissues. Although senescent cells undergo cell-cycle arrest, these cells remain metabolically active and their secretome — known as the senescence-associated secretory phenotype — is responsible for a systemic pro-inflammatory state, which contributes to an inflammatory microenvironment. Senescent cells can be found in the ageing prostate and the senescence-associated secretory phenotype and can be linked to BPH and prostate cancer. Indeed, a number of signalling pathways provide biological plausibility for the role of senescence in both BPH and prostate cancer, although proving causality is difficult. The theory of senescence as a mechanism for prostate disease has a number of clinical implications and could offer opportunities for targeting in the future.
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