Policarpo, R;
Sierksma, A;
De Strooper, B;
d'Ydewalle, C;
(2021)
From Junk to Function: LncRNAs in CNS Health and Disease.
Frontiers in Molecular Neuroscience
, 14
, Article 714768. 10.3389/fnmol.2021.714768.
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Abstract
Recent advances in RNA sequencing technologies helped to uncover the existence of tens of thousands of long non-coding RNAs (lncRNAs) that arise from the dark matter of the genome. These lncRNAs were originally thought to be transcriptional noise but an increasing number of studies demonstrate that these transcripts can modulate protein-coding gene expression by a wide variety of transcriptional and post-transcriptional mechanisms. The spatiotemporal regulation of lncRNA expression is particularly evident in the central nervous system, suggesting that they may directly contribute to specific brain processes, including neurogenesis and cellular homeostasis. Not surprisingly, lncRNAs are therefore gaining attention as putative novel therapeutic targets for disorders of the brain. In this review, we summarize the recent insights into the functions of lncRNAs in the brain, their role in neuronal maintenance, and their potential contribution to disease. We conclude this review by postulating how these RNA molecules can be targeted for the treatment of yet incurable neurological disorders.
| Type: | Article |
|---|---|
| Title: | From Junk to Function: LncRNAs in CNS Health and Disease |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3389/fnmol.2021.714768 |
| Publisher version: | https://doi.org/10.3389/fnmol.2021.714768 |
| Language: | English |
| Additional information: | Copyright © 2021 Policarpo, Sierksma, De Strooper and d’Ydewalle. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (http://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| Keywords: | long non-coding RNAs, central nervous system, neuronal development, neurological disorders, gene regulation |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UK Dementia Research Institute HQ |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10133508 |
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