Sayar, Z;
Nallamilli, S;
Efthymiou, M;
Lambert, J;
Cohen, H;
(2021)
Coexistent antiphospholipid syndrome and myeloproliferative neoplasm.
Lupus
, 30
(9)
pp. 1502-1508.
10.1177/09612033211021154.
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Abstract
Antiphospholipid syndrome (APS) and myeloproliferative neoplasms (MPN) are associated with an increased risk of thrombosis. The optimal management of patients with coexistent APS and MPN has not been defined. A single centre and systematic literature review of patients with coexistent APS and MPN was performed. Cases were divided into two groups based on whether they met international consensus criteria for APS. Of the 12 studies identified, eight were excluded (leaving five of a total 54 patients), as although antiphospholipid antibodies (aPL) were documented, the diagnosis of APS was not conclusively demonstrated. Another ten patients with definite APS were identified at our centre. Fifteen patients (ten females, five males) were therefore included in this analysis (eleven definite APS and four highly likely), median age 44 (range: 13–71) years. Nine had polycythaemia vera and six, essential thrombocythaemia. Thirteen of the 15 patients (86.7%) had thrombotic APS (seven with initial venous events and six arterial) and two (13.3%) had obstetric APS. Nine patients were single-positive, and six double-positive for aPL. None were triple aPL-positive. Four patients at our centre had recurrent thrombotic/obstetric events, including while on anticoagulation/antiplatelet treatment.
| Type: | Article |
|---|---|
| Title: | Coexistent antiphospholipid syndrome and myeloproliferative neoplasm |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1177/09612033211021154 |
| Publisher version: | https://doi.org/10.1177/09612033211021154 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Rheumatology, Myeloproliferative neoplasm, antiphospholipid syndrome, antiphospholipid antibodies, venous thromboembolism, arterial thrombosis, microvascular thrombosis, DIRECT ORAL ANTICOAGULANTS, HIGH-RISK, ESSENTIAL THROMBOCYTHEMIA, RECURRENT THROMBOSIS, POLYCYTHEMIA-VERA, CLINICAL-COURSE, ANTIBODIES, MANAGEMENT, WARFARIN, COMPLICATIONS, Myeloproliferative neoplasm, antiphospholipid syndrome, antiphospholipid antibodies, venous thromboembolism, arterial thrombosis, microvascular thrombosis |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10133858 |
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