Klaser, K;
(2021)
Deep MR to CT Synthesis for PET/MR Attenuation Correction.
Doctoral thesis (Ph.D), UCL (University College London).
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Abstract
Positron Emission Tomography - Magnetic Resonance (PET/MR) imaging combines the functional information from PET with the flexibility of MR imaging. It is essential, however, to correct for photon attenuation when reconstructing PETs, which is challenging for PET/MR as neither modality directly image tissue attenuation properties. Classical MR-based computed tomography (CT) synthesis methods, such as multi-atlas propagation, have been the method of choice for PET attenuation correction (AC), however, these methods are slow and suffer from the poor ability to handle anatomical abnormalities. To overcome this limitation, this thesis explores the rising field of artificial intelligence in order to develop novel methods for PET/MR AC. Deep learning-based synthesis methods such as the standard U-Net architecture are not very stable, accurate, and robust to small variations in image appearance. Thus, the first proposed MR to CT synthesis method deploys a boosting strategy, where multiple weak predictors build a strong predictor providing a significant improvement in CT and PET reconstruction accuracy. Standard deep learning-based methods as well as more advanced methods like the first proposed method show issues in the presence of very complex imaging environments and large images such as whole-body images. The second proposed method learns the image context between whole-body MRs and CTs through multiple resolutions while simultaneously modelling uncertainty. Lastly, as the purpose of synthesizing a CT is to better reconstruct PET data, the use of CT-based loss functions is questioned within this thesis. Such losses fail to recognize the main objective of MR-based AC, which is to generate a synthetic CT that, when used for PET AC, makes the reconstructed PET as close as possible to the gold standard PET. The third proposed method introduces a novel PET-based loss that minimizes CT residuals with respect to the PET reconstruction.
| Type: | Thesis (Doctoral) |
|---|---|
| Qualification: | Ph.D |
| Title: | Deep MR to CT Synthesis for PET/MR Attenuation Correction |
| Event: | UCL |
| Open access status: | An open access version is available from UCL Discovery |
| Language: | English |
| Additional information: | Copyright © The Author 2021. Original content in this thesis is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) Licence (https://creativecommons.org/licenses/by-nc/4.0/). Any third-party copyright material present remains the property of its respective owner(s) and is licensed under its existing terms. Access may initially be restricted at the author’s request. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10134454 |
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