Chatterjee, P;
Pedrini, S;
Ashton, NJ;
Tegg, M;
Goozee, K;
Singh, AK;
Karikari, TK;
... Martins, RN; + view all
(2022)
Diagnostic and prognostic plasma biomarkers for preclinical Alzheimer's disease.
Alzheimer's & Dementia
, 18
(6)
pp. 1141-1154.
10.1002/alz.12447.
Preview |
Text
Zetterberg_Chatterjee.pdf Download (389kB) | Preview |
Abstract
INTRODUCTION: This study involved a parallel comparison of the diagnostic and longitudinal monitoring potential of plasma glial fibrillary acidic protein (GFAP), total tau (t-tau), phosphorylated tau (p-tau181 and p-tau231), and neurofilament light (NFL) in preclinical Alzheimer's disease (AD). METHODS: Plasma proteins were measured using Simoa assays in cognitively unimpaired older adults (CU), with either absence (Aβ−) or presence (Aβ+) of brain amyloidosis. RESULTS: Plasma GFAP, t-tau, p-tau181, and p-tau231 concentrations were higher in Aβ+ CU compared with Aβ− CU cross-sectionally. GFAP had the highest effect size and area under the curve (AUC) in differentiating between Aβ+ and Aβ− CU; however, no statistically significant differences were observed between the AUCs of GFAP, p-tau181, and p-tau231, but all were significantly higher than the AUC of NFL, and the AUC of GFAP was higher than the AUC of t-tau. The combination of a base model (BM), comprising the AD risk factors, age, sex, and apolipoprotein E gene (APOE) ε4 status with GFAP was observed to have a higher AUC (>90%) compared with the combination of BM with any of the other proteins investigated in the current study. Longitudinal analyses showed increased GFAP and p-tau181 in Aβ+ CU and increased NFL in Aβ− CU, over a 12-month duration. GFAP, p-tau181, p-tau231, and NFL showed significant correlations with cognition, whereas no significant correlations were observed with hippocampal volume. DISCUSSION: These findings highlight the diagnostic and longitudinal monitoring potential of GFAP and p-tau for preclinical AD.
| Type: | Article |
|---|---|
| Title: | Diagnostic and prognostic plasma biomarkers for preclinical Alzheimer's disease |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/alz.12447 |
| Publisher version: | https://doi.org/10.1002/alz.12447 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Alzheimer's disease, amyloid beta, blood biomarkers, brain amyloid beta, diagnosis, glial fibrillary acidic protein, longitudinal monitoring, neurofilament light, p-tau181, p-tau231, preclinical Alzheimer's disease, single molecule array, tau |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10134950 |
Archive Staff Only
 |
View Item |
