Hajishengallis, G;
Hasturk, H;
Lambris, JD;
Apatzidou, DA;
Belibasakis, GN;
Bostanci, N;
Corby, PM;
... Yancopoulou, D; + view all
(2021)
C3-targeted therapy in periodontal disease: moving closer to the clinic.
Trends in Immunology
, 42
(10)
pp. 856-864.
10.1016/j.it.2021.08.001.
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Abstract
Complement plays a key role in immunosurveillance and homeostasis. When dysregulated or overactivated, complement can become a pathological effector, as seen in several inflammatory disorders, including periodontal disease. Recently, clinical correlative studies and preclinical mechanistic investigations have collectively demonstrated that complement is hyperactivated during periodontitis and that targeting its central component (C3) provides therapeutic benefit in nonhuman primates (NHPs). The preclinical efficacy of a C3-targeted drug candidate combined with excellent safety and pharmacokinetic profiles supported its use in a recent Phase IIa clinical study in which C3 inhibition resolved gingival inflammation in patients with periodontal disease. We posit that C3-targeted intervention might represent a novel and transformative host-modulation therapy meriting further investigation in Phase III clinical trials for the treatment of periodontitis.
| Type: | Article |
|---|---|
| Title: | C3-targeted therapy in periodontal disease: moving closer to the clinic |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.it.2021.08.001 |
| Publisher version: | https://doi.org/10.1016/j.it.2021.08.001 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > Restorative Dental Sciences |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10135112 |
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