Lau, YS;
Chew, MT;
Alqahtani, A;
Jones, B;
Hill, MA;
Nisbet, A;
Bradley, DA;
(2021)
Low dose ionising radiation-induced hormesis: Therapeutic implications to human health.
Applied Sciences
, 11
(19)
, Article 8909. 10.3390/app11198909.
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Abstract
The concept of radiation-induced hormesis, whereby a low dose is beneficial and a high dose is detrimental, has been gaining attention in the fields of molecular biology, environmental toxicology and radiation biology. There is a growing body of literature that recognises the importance of hormetic dose response not only in the radiation field, but also with molecular agents. However, there is continuing debate on the magnitude and mechanism of radiation hormetic dose response, which could make further contributions, as a research tool, to science and perhaps eventually to public health due to potential therapeutic benefits for society. The biological phenomena of low dose ionising radiation (LDIR) includes bystander effects, adaptive response, hypersensitivity, radioresistance and genomic instability. In this review, the beneficial and the detrimental effects of LDIR-induced hormesis are explored, together with an overview of its underlying cellular and molecular mechanisms that may potentially provide an insight to the therapeutic implications to human health in the future.
| Type: | Article |
|---|---|
| Title: | Low dose ionising radiation-induced hormesis: Therapeutic implications to human health |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3390/app11198909 |
| Publisher version: | https://doi.org/10.3390/app11198909 |
| Language: | English |
| Additional information: | This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited |
| Keywords: | radiation-induced hormesis; bystander effects; adaptive response; hypersensitivity; radioresistance; genomic instability |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10135248 |
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