Mattley, Jane; (2021) Auditory Processing Deficits in Mouse Models of Developmental Disorders. Doctoral thesis (Ph.D), UCL (University College London).

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Abstract

BXSB/MpJ-Yaa mice are a model of neurodevelopmental disorders where some animals have cortical malformations, called ectopia. Mice with ectopias are impaired at detecting short gaps in noise compared to the mice without ectopias both behaviourally and neurally in auditory thalamus (Anderson & Linden, 2016; Clark, et al., 2000; Frenkel et al., 2000). We made auditory brainstem recordings (ABRs) and extracellular recordings in the inferior colliculus (IC). Central IC cells were found to have shorter gap-detection thresholds in ectopic compared to non-ectopic mice. ABRs suggest there is no difference between auditory processing in early area of the auditory pathway. Histological analysis suggests the deficit does not arise in auditory cortex or thalamus. So the deficit appears to arise in the IC or between IC and thalamus. Additionally, we investigate auditory processing in KO mice for two genes associated with the neurodevelopmental disorder, dyslexia. We performed ABRs on these mice and found suprathreshold changes in some ABR waves which appears to be more severe in a KO mouse for both candidate genes. So in some animal models of neurodevelopmental disorders deficits in auditory processing can arise early in the auditory pathway below the level of IC.

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