Zar, HJ;
Nicol, MP;
MacGinty, R;
Workman, L;
Petersen, W;
Johnson, M;
Goldblatt, D;
(2021)
Antibodies to Seasonal Coronaviruses Rarely Cross-React with SARS-CoV-2: Findings from an African Birth Cohort.
The Pediatric Infectious Disease Journal
, 40
(12)
e516-e519.
10.1097/INF.0000000000003325.
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Abstract
Antibodies to seasonal human-coronaviruses (sHCoV) may cross-protect against SARS-CoV-2. We investigated antibody responses in biobanked serum obtained before the pandemic from infants with polymerase chain reaction-confirmed sHCoV. Among 141 samples with antibodies to sHCoV, 4 (2.8%) were positive for SARS-CoV-2-S1 and 8 (5.7%) for SARS-CoV-2-S2. Antibodies to sHCoV rarely cross-react with SARS-CoV-2 antigens and are unlikely to account for mild pediatric illness.
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