Csincsik, L;
Quinn, N;
Yong, KXX;
Crutch, SJ;
Peto, T;
Lengyel, I;
(2021)
Retinal phenotyping of variants of Alzheimer's disease using ultra-widefield retinal images.
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
, 13
(1)
, Article e12232. 10.1002/dad2.12232.
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Alz Dem Diag Ass Dis Mo - 2021 - Csincsik - Retinal phenotyping of variants of Alzheimer s disease using.pdf Download (6MB) | Preview |
Abstract
Background: Posterior cortical atrophy (PCA) is the most common atypical variant of Alzheimer's disease (AD). Changes associated with PCA in the brain affect the visual cortex, but little is known about retinal changes in PCA. In this study, we explored retinal phenotypic variations in typical AD (tAD) and PCA. Methods: Retinal phenotyping was carried out on ultra-widefield (UWF) images of 69 control, 24 tAD, and 25 PCA participants. Results: Individuals with tAD (odds ratio [OR] = 2.76 [confidence interval (CI):1.24 to 6.10], P = .012) and PCA (OR = 3.40 [CI:1.25 to 9.22], P = .016) were more likely phenotyped as hard drusen. tAD (OR = 0.34 [CI:0.12 to 0.92], P = .035) were less likely to have soft drusen compared to control. Almost 3-fold increase in reticular pseudodrusen formation in tAD (OR = 2.93 [CI:1.10 to 7.76], P = .030) compared to control was estimated. Discussion: Studying the peripheral retina may contribute to a better understanding of differences in retinal phenotypes of different AD variants.
| Type: | Article |
|---|---|
| Title: | Retinal phenotyping of variants of Alzheimer's disease using ultra-widefield retinal images |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/dad2.12232 |
| Publisher version: | https://doi.org/10.1002/dad2.12232 |
| Language: | English |
| Additional information: | This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited |
| Keywords: | Alzheimer's disease, drusen, peripheral reticular pigmentary degeneration, posterior cortical atrophy, reticular pseudodrusen, retinal imaging, retinal phenotype, sub‐retinal deposit, ultra‐widefield imaging |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10135820 |
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