Shahim, P;
Zetterberg, H;
(2021)
Neurochemical markers of traumatic brain injury – relevance to acute diagnostics, disease monitoring, and neuropsychiatric outcome prediction.
Biological Psychiatry
10.1016/j.biopsych.2021.10.010.
(In press).
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Abstract
Considerable advancements have been made in the quantification of biofluid-based biomarkers for traumatic brain injury (TBI), which provide a clinically accessible window to investigate disease mechanisms and progression. Methods with improved analytical sensitivity compared with standard immunoassays are increasingly utilized, which has opened for the use of blood tests in the diagnosis, monitoring, and outcome prediction of TBI. Most work to date has focused on acute TBI diagnostics, whilst the literature on biomarkers for long-term sequelae is relatively scarce. In this review, we give an update on the latest developments in biofluid-based biomarker research in TBI and discuss how acute and prolonged biomarker changes can be used to detect and quantify brain injury and predict clinical outcome and neuropsychiatric sequelae.
| Type: | Article |
|---|---|
| Title: | Neurochemical markers of traumatic brain injury – relevance to acute diagnostics, disease monitoring, and neuropsychiatric outcome prediction |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.biopsych.2021.10.010 |
| Publisher version: | https://doi.org/10.1016/j.biopsych.2021.10.010 |
| Language: | English |
| Additional information: | © 2021 Published by Elsevier Ltd. This is an open access article under the CC BY 4.0 license Attribution 4.0 International (https://creativecommons.org/licenses/by/4.0/) |
| Keywords: | head trauma, traumatic brain injury, biomarkers, neurofilament, tau, glial fibrillary acidic protein |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10137649 |
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