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A comprehensive score reflecting memory-related fMRI activations and deactivations as potential biomarker for neurocognitive aging

Soch, J; Richter, A; Schuetze, H; Kizilirmak, JM; Assmann, A; Behnisch, G; Feldhoff, H; ... Schott, BH; + view all (2021) A comprehensive score reflecting memory-related fMRI activations and deactivations as potential biomarker for neurocognitive aging. Human Brain Mapping , 42 (14) pp. 4478-4496. 10.1002/hbm.25559. Green open access

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Abstract

Older adults and particularly those at risk for developing dementia typically show a decline in episodic memory performance, which has been associated with altered memory network activity detectable via functional magnetic resonance imaging (fMRI). To quantify the degree of these alterations, a score has been developed as a putative imaging biomarker for successful aging in memory for older adults (Functional Activity Deviations during Encoding, FADE; Düzel et al., Hippocampus, 2011; 21: 803–814). Here, we introduce and validate a more comprehensive version of the FADE score, termed FADE-SAME (Similarity of Activations during Memory Encoding), which differs from the original FADE score by considering not only activations but also deactivations in fMRI contrasts of stimulus novelty and successful encoding, and by taking into account the variance of young adults' activations. We computed both scores for novelty and subsequent memory contrasts in a cohort of 217 healthy adults, including 106 young and 111 older participants, as well as a replication cohort of 117 young subjects. We further tested the stability and generalizability of both scores by controlling for different MR scanners and gender, as well as by using different data sets of young adults as reference samples. Both scores showed robust agegroup-related differences for the subsequent memory contrast, and the FADE-SAME score additionally exhibited age-group-related differences for the novelty contrast. Furthermore, both scores correlate with behavioral measures of cognitive aging, namely memory performance. Taken together, our results suggest that single-value scores of memory-related fMRI responses may constitute promising biomarkers for quantifying neurocognitive aging.

Type: Article
Title: A comprehensive score reflecting memory-related fMRI activations and deactivations as potential biomarker for neurocognitive aging
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/hbm.25559
Publisher version: https://doi.org/10.1002/hbm.25559
Language: English
Additional information: © 2021 The Authors. Human Brain Mapping published by Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
Keywords: cognitive aging, episodic memory, fMRI, hippocampus, memory impairment, subsequent memory effect, BRAIN ACTIVITY, SUBSEQUENT MEMORY, SEGMENTATION, METAANALYSIS, REDUCTION, RETRIEVAL, PATTERNS, PREDICTS, RISK, MINI
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Institute of Cognitive Neuroscience
URI: https://discovery-pp.ucl.ac.uk/id/eprint/10138379
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