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Platinum binding preferences dominate the binding of novel polyamide amidine anthraquinone platinum(II) complexes to DNA

Lo, ATS; Chen, JK; Murray, V; Todd, MH; Hambley, TW; (2021) Platinum binding preferences dominate the binding of novel polyamide amidine anthraquinone platinum(II) complexes to DNA. Dalton Transactions , 50 (48) pp. 17945-17952. 10.1039/d1dt03539h. Green open access

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Abstract

Complexes incorporating a threading anthraquinone intercalator with pyrrole lexitropsin and platinum(II) moieties attached were developed with the goal of generating novel DNA binding modes, including the targeting of AT-rich regions in order to have high cytotoxicities. The binding of the complexes to DNA has been investigated and profiles surprisingly similar to that for cisplatin were observed; the profiles were different to those for a complex lacking the pyrrole lexitropsin component. The lack of selective binding to AT-rich regions suggests the platinum binding was dominating the sequence selectivity, and is consistent with the pyrrole lexitropsin slowing intercalation. The DNA unwinding profiles following platinum binding were evaluated by gel electrophoresis and suggested that intercalation and platinum binding were both occurring.

Type: Article
Title: Platinum binding preferences dominate the binding of novel polyamide amidine anthraquinone platinum(II) complexes to DNA
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1039/d1dt03539h
Publisher version: http://dx.doi.org/10.1039/d1dt03539h
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharma and Bio Chemistry
URI: https://discovery-pp.ucl.ac.uk/id/eprint/10139623
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