Yoo, J;
Kerkela, L;
Hales, PW;
Seunarine, KK;
Clark, CA;
(2021)
High-resolution microscopic diffusion anisotropy imaging in the human hippocampus at 3T.
Magnetic Resonance in Medicine
10.1002/mrm.29104.
(In press).
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Abstract
Purpose Several neurological conditions are associated with microstructural changes in the hippocampus that can be observed using DWI. Imaging studies often use protocols with whole-brain coverage, imposing limits on image resolution and worsening partial-volume effects. Also, conventional single-diffusion-encoding methods confound microscopic diffusion anisotropy with size variance of microscopic diffusion environments. This study addresses these issues by implementing a multidimensional diffusion-encoding protocol for microstructural imaging of the hippocampus at high resolution. Methods The hippocampus of 8 healthy volunteers was imaged at 1.5-mm isotropic resolution with a multidimensional diffusion-encoding sequence developed in house. Microscopic fractional anisotropy (µFA) and normalized size variance (CMD) were estimated using q-space trajectory imaging, and their values were compared with DTI metrics. The overall scan time was 1 hour. The reproducibility of the protocol was confirmed with scan–rescan experiments, and a shorter protocol (14 minutes) was defined for situations with time constraints. Results Mean µFA (0.47) was greater than mean FA (0.20), indicating orientation dispersion in hippocampal tissue microstructure. Mean CMD was 0.17. The reproducibility of q-space trajectory imaging metrics was comparable to DTI, and microstructural metrics in the healthy hippocampus are reported. Conclusion This work shows the feasibility of high-resolution microscopic anisotropy imaging in the human hippocampus at 3 T and provides reference values for microstructural metrics in a healthy hippocampus.
| Type: | Article |
|---|---|
| Title: | High-resolution microscopic diffusion anisotropy imaging in the human hippocampus at 3T |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/mrm.29104 |
| Publisher version: | https://doi.org/10.1002/mrm.29104 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third-party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Radiology, Nuclear Medicine & Medical Imaging, b-tensor encoding, diffusion, hippocampus, microscopic fractional anisotropy, q-space trajectory imaging, spherical tensor encoding, MILD COGNITIVE IMPAIRMENT, MICROSTRUCTURAL CHANGES, MR DIFFUSION, TENSOR, MEMORY, SPACE, VIVO, QUANTIFICATION, SCHIZOPHRENIA, VULNERABILITY |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Neurosciences Dept |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10140042 |
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