Agrawal, A;
Wang, K;
Polonchuk, L;
Cooper, J;
Mirams, GR;
Gavaghan, DJ;
Clerx, M;
(2021)
Models of the cardiac L-type calcium current: a quantitative comparison.
Cold Spring Harbor Laboratory
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Abstract
The L-type calcium current (ICaL) plays a critical role in cardiac electrophysiology, and models of ICaL are vital tools to predict arrhythmogenicity of drugs and mutations. Five decades of measuring and modelling ICaL have resulted in several competing theories (encoded in mathematical equations). However, the introduction of new models has not typically been accompanied by a data-driven critical comparison with previous work, so that it is unclear where predictions overlap or conflict, or which model is best suited for any particular application. We gathered 71 mammalian ICaL models, compared their structure, and reproduced simulated experiments to show that there is a large variability in their predictions, which was not substantially diminished when grouping by species or other categories. By highlighting the differences in these competing theories, listing major data sources, and providing simulation code, we have laid strong foundations for the development of a consensus model of ICaL.
| Type: | Working / discussion paper |
|---|---|
| Title: | Models of the cardiac L-type calcium current: a quantitative comparison |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1101/2021.10.04.462988 |
| Publisher version: | https://doi.org/10.1101/2021.10.04.462988 |
| Language: | English |
| Additional information: | The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license. |
| UCL classification: | UCL |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10140308 |
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