Suárez-González, A;
Savage, SA;
Bier, N;
Henry, ML;
Jokel, R;
Nickels, L;
Taylor-Rubin, C;
(2021)
Semantic variant primary progressive aphasia: Practical recommendations for treatment from 20 years of behavioural research.
Brain Sciences
, 11
(12)
, Article 1552. 10.3390/brainsci11121552.
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Abstract
People with semantic variant primary progressive aphasia (svPPA) present with a char-acteristic progressive breakdown of semantic knowledge. There are currently no pharmacological interventions to cure or slow svPPA, but promising behavioural approaches are increasingly reported. This article offers an overview of the last two decades of research into interventions to support language in people with svPPA including recommendations for clinical practice and future research based on the best available evidence. We offer a lay summary in English, Spanish and French for education and dissemination purposes. This paper discusses the implications of right-versus left-predominant atrophy in svPPA, which naming therapies offer the best outcomes and how to capitalise on preserved long-term memory systems. Current knowledge regarding the maintenance and generalisation of language therapy gains is described in detail along with the development of compensatory approaches and educational and support group programmes. It is concluded that there is evidence to support an integrative framework of treatment and care as best practice for svPPA. Such an approach should combine rehabilitation interventions addressing the language impairment, compensatory approaches to support activities of daily living and provision of education and support within the context of dementia.
| Type: | Article |
|---|---|
| Title: | Semantic variant primary progressive aphasia: Practical recommendations for treatment from 20 years of behavioural research |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3390/brainsci11121552 |
| Publisher version: | https://doi.org/10.3390/brainsci11121552 |
| Language: | English |
| Additional information: | This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited |
| Keywords: | Semantic dementia; semantic variant primary progressive aphasia; word finding; frontotemporal dementia; language therapy; behavioural therapy |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10140351 |
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