Paquola, C;
Royer, J;
Lewis, LB;
Lepage, C;
Glatard, T;
Wagstyl, K;
DeKraker, J;
... Bernhardt, B; + view all
(2021)
The BigBrainWarp toolbox for integration of BigBrain 3D histology with multimodal neuroimaging.
eLife
, 10
, Article e70119. 10.7554/eLife.70119.
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Abstract
Neuroimaging stands to benefit from emerging ultrahigh-resolution 3D histological atlases of the human brain; the first of which is ‘BigBrain’. Here, we review recent methodological advances for the integration of BigBrain with multi-modal neuroimaging and introduce a toolbox, ’BigBrainWarp’, that combines these developments. The aim of BigBrainWarp is to simplify workflows and support the adoption of best practices. This is accomplished with a simple wrapper function that allows users to easily map data between BigBrain and standard MRI spaces. The function automatically pulls specialised transformation procedures, based on ongoing research from a wide collaborative network of researchers. Additionally, the toolbox improves accessibility of histological information through dissemination of ready-to-use cytoarchitectural features. Finally, we demonstrate the utility of BigBrainWarp with three tutorials and discuss the potential of the toolbox to support multi-scale investigations of brain organisation.
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