Frank, B;
Ally, M;
Brekke, B;
Zetterberg, H;
Blennow, K;
Sugarman, MA;
Ashton, NJ;
... Alosco, ML; + view all
(2022)
Plasma p-tau₁₈₁ shows stronger network association to Alzheimer's disease dementia than neurofilament light and total tau.
Alzheimer's & Dementia
, 18
(8)
pp. 1523-1536.
10.1002/alz.12508.
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Abstract
Introduction: We examined the ability of plasma hyperphosphorylated tau (p-tau)181 to detect cognitive impairment due to Alzheimer's disease (AD) independently and in combination with plasma total tau (t-tau) and neurofilament light (NfL). / Methods: Plasma samples were analyzed using the Simoa platform for 235 participants with normal cognition (NC), 181 with mild cognitive impairment due to AD (MCI), and 153 with AD dementia. Statistical approaches included multinomial regression and Gaussian graphical models (GGMs) to assess a network of plasma biomarkers, neuropsychological tests, and demographic variables. / Results: Plasma p-tau181 discriminated AD dementia from NC, but not MCI, and correlated with dementia severity and worse neuropsychological test performance. Plasma NfL similarly discriminated diagnostic groups. Unlike plasma NfL or t-tau, p-tau181 had a direct association with cognitive diagnosis in a bootstrapped GGM. / Discussion: These results support plasma p-tau181 for the detection of AD dementia and the use of blood-based biomarkers for optimal disease detection.
| Type: | Article |
|---|---|
| Title: | Plasma p-tau₁₈₁ shows stronger network association to Alzheimer's disease dementia than neurofilament light and total tau |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/alz.12508 |
| Publisher version: | https://doi.org/10.1002/alz.12508 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Alzheimer's Disease, P-tau, Plasma biomarkers, Network analysis, Neuropsychology |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10141638 |
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