Cheung, JPY;
Kuang, X;
Lai, MKL;
Cheung, KM-C;
Karppinen, J;
Samartzis, D;
Wu, H;
... Zhang, T; + view all
(2022)
Learning-based fully automated prediction of lumbar disc degeneration progression with specified clinical parameters and preliminary validation.
European Spine Journal
, 31
pp. 1960-1968.
10.1007/s00586-021-07020-x.
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Abstract
Background: Lumbar disc degeneration (LDD) may be related to aging, biomechanical and genetic factors. Despite the extensive work on understanding its etiology, there is currently no automated tool for accurate prediction of its progression. / Purpose: We aim to establish a novel deep learning-based pipeline to predict the progression of LDD-related findings using lumbar MRIs. / Materials and methods: We utilized our dataset with MRIs acquired from 1,343 individual participants (taken at the baseline and the 5-year follow-up timepoint), and progression assessments (the Schneiderman score, disc bulging, and Pfirrmann grading) that were labelled by spine specialists with over ten years clinical experience. Our new pipeline was realized by integrating the MRI-SegFlow and the Visual Geometry Group-Medium (VGG-M) for automated disc region detection and LDD progression prediction correspondingly. The LDD progression was quantified by comparing the Schneiderman score, disc bulging and Pfirrmann grading at the baseline and at follow-up. A fivefold cross-validation was conducted to assess the predictive performance of the new pipeline. / Results: Our pipeline achieved very good performances on the LDD progression prediction, with high progression prediction accuracy of the Schneiderman score (Accuracy: 90.2 ± 0.9%), disc bulging (Accuracy: 90.4% ± 1.1%), and Pfirrmann grading (Accuracy: 89.9% ± 2.1%). / Conclusion: This is the first attempt of using deep learning to predict LDD progression on a large dataset with 5-year follow-up. Requiring no human interference, our pipeline can potentially achieve similar predictive performances in new settings with minimal efforts.
| Type: | Article |
|---|---|
| Title: | Learning-based fully automated prediction of lumbar disc degeneration progression with specified clinical parameters and preliminary validation |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1007/s00586-021-07020-x |
| Publisher version: | https://doi.org/10.1007/s00586-021-07020-x |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Lumbar disc degeneration, Convolutional neural network, Magnetic resonance imaging, Disease progression prediction |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Health Informatics |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10141713 |
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