Venkatesan, S;
Angelova, M;
Bartkova, J;
Bakhoum, SF;
Bartek, J;
Kanu, N;
Swanton, C;
(2021)
APOBEC3 as a driver of genetic intratumor heterogeneity.
Molecular and Cellular Oncology
10.1080/23723556.2021.2014734.
(In press).
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Abstract
Our recent study revealed that APOBEC3B is upregulated during the preinvasive stages of non-small cell lung cancer and breast cancer. In addition to its role in mediating single nucleotide variants, we propose that APOBEC3 promotes copy number intratumor heterogeneity prior to invasion, providing a substrate for cancer evolution.
| Type: | Article |
|---|---|
| Title: | APOBEC3 as a driver of genetic intratumor heterogeneity |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1080/23723556.2021.2014734 |
| Publisher version: | https://doi.org/10.1080/23723556.2021.2014734 |
| Language: | English |
| Additional information: | © 2021 The Author(s). Published with license by Taylor & Francis Group, LLC. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | APOBEC, non-small cell lung cancer, breast cancer, intratumor heterogeneity, chromosomal instability |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10142128 |
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