Antelmi, E;
Rocchi, L;
Latorre, A;
Belvisi, D;
Magrinelli, F;
Bhatia, KP;
Tinazzi, M;
(2022)
Restless Legs Syndrome: Known Knowns and Known Unknowns.
Brain Sciences
, 12
(1)
, Article 118. 10.3390/brainsci12010118.
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Abstract
Although restless legs syndrome (RLS) is a common neurological disorder, it remains poorly understood from both clinical and pathophysiological perspectives. RLS is classified among sleep-related movement disorders, namely, conditions characterized by simple, often stereotyped movements occurring during sleep. However, several clinical, neurophysiological and neuroimaging observations question this view. The aim of the present review is to summarize and query some of the current concepts (known knowns) and to identify open questions (known unknowns) on RLS pathophysiology. Based on several lines of evidence, we propose that RLS should be viewed as a disorder of sensorimotor interaction with a typical circadian pattern of occurrence, possibly arising from neurochemical dysfunction and abnormal excitability in different brain structures.
| Type: | Article |
|---|---|
| Title: | Restless Legs Syndrome: Known Knowns and Known Unknowns |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3390/brainsci12010118 |
| Publisher version: | https://doi.org/10.3390/brainsci12010118 |
| Language: | English |
| Additional information: | This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | restless legs syndrome; sleep-related movement disorder; sensorimotor interaction; circadian disorders; dopamine; iron; sensory gating |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10142401 |
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