Phung, Minh Tung;
Alimujiang, Aliya;
Berchuck, Andrew;
Anton-Cluver, Hoda;
Schildkraut, Joellen M;
Bandera, Elisa V;
Chang-Claude, Jenny;
... Pearce, Celeste Leigh; + view all
(2022)
Reproductive Factors Do Not Influence Survival with Ovarian Cancer.
Cancer Epidemiology Biomarkers & Prevention
, 31
(4)
pp. 909-913.
10.1158/1055-9965.EPI-21-1091.
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Abstract
Background: Previous studies on the association between reproductive factors and ovarian cancer survival are equivocal, possibly due to small sample sizes. Methods: Using data on 11,175 people diagnosed with primary invasive epithelial ovarian, fallopian tube, or primary peritoneal cancer (ovarian cancer) from 16 studies in the Ovarian Cancer Association Consortium (OCAC), we examined the associations between survival and age at menarche, combined oral contraceptive use, parity, breastfeeding, age at last pregnancy, and menopausal status using Cox proportional hazard models. The models were adjusted for age at diagnosis, race/ethnicity, education level, and OCAC study and stratified on stage and histotype. Results: During the mean follow-up of 6.34 years (SD=4.80), 6,418 patients passed away (57.4%). There was no evidence of associations between the reproductive factors and survival among ovarian cancer patients overall or by histotype. Conclusions: This study found no association between reproductive factors and survival after an ovarian cancer diagnosis. ImpactReproductive factors are well-established risk factors for ovarian cancer, but they are not associated with survival after a diagnosis of ovarian cancer.
| Type: | Article |
|---|---|
| Title: | Reproductive Factors Do Not Influence Survival with Ovarian Cancer |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1158/1055-9965.EPI-21-1091 |
| Publisher version: | https://doi.org/10.1158/1055-9965.EPI-21-1091 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology > MRC Clinical Trials Unit at UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10143540 |
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