Watt, Jennifer A;
Del Giovane, Cinzia;
Jackson, Dan;
Turner, Rebecca M;
Tricco, Andrea C;
Mavridis, Dimitris;
Straus, Sharon E;
(2022)
Incorporating dose effects in network meta-analysis.
BMJ
, 376
, Article e067003. 10.1136/bmj-2021-067003.
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Abstract
Systematic reviews with network meta-analysis that ignore potential dose effects could limit the applicability and validity of review findings. This article aims to help content experts (eg, clinicians), methodologists, and statisticians better understand how to incorporate dose effects in network meta-analysis. Three models are described that make different clinical and statistical assumptions about how to model dose effects. This article also illustrates the importance of dose effects in understanding the potential risk of harm in people with dementia from cerebrovascular events associated with atypical antipsychotic drug use (quetiapine, olanzapine, and risperidone) and the potential risk of harm in people with nausea and headache associated with cholinesterase inhibitor use (donepezil, galantamine, and rivastigmine). Finally, important considerations when choosing between different network meta-analysis models incorporating dose effects are discussed.
| Type: | Article |
|---|---|
| Title: | Incorporating dose effects in network meta-analysis |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1136/bmj-2021-067003 |
| Publisher version: | https://doi.org/10.1136/bmj-2021-067003 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions. |
| Keywords: | Antipsychotic Agents, Cholinesterase Inhibitors, Data Interpretation, Statistical, Dementia, Dose-Response Relationship, Drug, Headache, Humans, Nausea, Network Meta-Analysis, Outcome Assessment, Health Care, Reproducibility of Results, Stroke, Systematic Reviews as Topic |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology > MRC Clinical Trials Unit at UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10143604 |
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