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Morphogen gradient scaling by recycling of intracellular Dpp

Romanova-Michaelides, M; Hadjivasiliou, Z; Aguilar-Hidalgo, D; Basagiannis, D; Seum, C; Dubois, M; Jülicher, F; (2022) Morphogen gradient scaling by recycling of intracellular Dpp. Nature , 602 (7896) pp. 287-293. 10.1038/s41586-021-04346-w. Green open access

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Abstract

Morphogen gradients are fundamental to establish morphological patterns in developing tissues1. During development, gradients scale to remain proportional to the size of growing organs2,3. Scaling is a universal gear that adjusts patterns to size in living organisms3–8, but its mechanisms remain unclear. Here, focusing on the Decapentaplegic (Dpp) gradient in the Drosophila wing disc, we uncover a cell biological basis behind scaling. From small to large discs, scaling of the Dpp gradient is achieved by increasing the contribution of the internalized Dpp molecules to Dpp transport: to expand the gradient, endocytosed molecules are re-exocytosed to spread extracellularly. To regulate the contribution of endocytosed Dpp to the spreading extracellular pool during tissue growth, it is the Dpp binding rates that are progressively modulated by the extracellular factor Pentagone, which drives scaling. Thus, for some morphogens, evolution may act on endocytic trafficking to regulate the range of the gradient and its scaling, which could allow the adaptation of shape and pattern to different sizes of organs in different species.

Type: Article
Title: Morphogen gradient scaling by recycling of intracellular Dpp
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/s41586-021-04346-w
Publisher version: https://doi.org/10.1038/s41586-021-04346-w
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
UCL classification: UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > London Centre for Nanotechnology
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL
URI: https://discovery-pp.ucl.ac.uk/id/eprint/10144833
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