McCoubrey, LE;
Elbadawi, M;
Basit, AW;
(2022)
Current clinical translation of microbiome medicines.
Trends in Pharmacological Sciences
, 43
(4)
pp. 281-292.
10.1016/j.tips.2022.02.001.
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Abstract
The microbiome is experiencing increasing scrutiny for its role in disease, and the number of new research reports describing microbiome–disease relationships is growing exponentially. Researchers are increasingly working to translate the emerging fundamental science into microbiome medicines that will address important unmet needs in the clinic. We summarise the types of microbiome medicines that have the most translational potential, and provide a detailed analysis of the current global microbiome medicines pipeline and the challenges facing clinical translation. The regulatory pipeline is currently dominated by probiotics intended for oral delivery to the gastrointestinal (GI) tract; however, several non-living biologics and small molecules provide notable exceptions. With the first microbiome medicine set to begin the regulatory submission process in 2022, it is an exciting time for the field.
| Type: | Article |
|---|---|
| Title: | Current clinical translation of microbiome medicines |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.tips.2022.02.001 |
| Publisher version: | https://doi.org/10.1016/j.tips.2022.02.001 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions. |
| Keywords: | biotechnology, drug discovery and development, dysbiosis, microbiota, peptide therapeutics, postbiotics |
| UCL classification: | UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10145421 |
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