Li, Jiayao;
Liu, Yinan;
Abdelhakim, Hend E;
(2022)
Drug Delivery Applications of Coaxial Electrospun Nanofibres in Cancer Therapy.
Molecules
, 27
(6)
, Article 1803. 10.3390/molecules27061803.
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Abstract
Cancer is one of the most serious health problems and the second leading cause of death worldwide, and with an ageing and growing population, problems related to cancer will continue. In the battle against cancer, many therapies and anticancer drugs have been developed. Chemotherapy and relevant drugs are widely used in clinical practice; however, their applications are always accompanied by severe side effects. In recent years, the drug delivery system has been improved by nanotechnology to reduce the adverse effects of the delivered drugs. Among the different candidates, core–sheath nanofibres prepared by coaxial electrospinning are outstanding due to their unique properties, including their large surface area, high encapsulation efficiency, good mechanical property, multidrug loading capacity, and ability to govern drug release kinetics. Therefore, encapsulating drugs in coaxial electrospun nanofibres is a desirable method for controlled and sustained drug release. This review summarises the drug delivery applications of coaxial electrospun nanofibres with different structures and drugs for various cancer treatments.
| Type: | Article |
|---|---|
| Title: | Drug Delivery Applications of Coaxial Electrospun Nanofibres in Cancer Therapy |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3390/molecules27061803 |
| Publisher version: | https://doi.org/10.3390/molecules27061803 |
| Language: | English |
| Additional information: | © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). |
| Keywords: | coaxial nanofibres; electrospinning; cancer therapy; drug delivery; applications |
| UCL classification: | UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10145618 |
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