Patel, Sandip;
Yuan, Yu;
Gunaratne, Gihan S;
Rahman, Taufiq;
Marchant, Jonathan S;
(2022)
Activation of endo-lysosomal two-pore channels by NAADP and PI(3,5)P2. Five things to know.
Cell Calcium
, 103
, Article 102543. 10.1016/j.ceca.2022.102543.
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Abstract
Two-pore channels are ancient members of the voltage-gated ion channel superfamily that are expressed predominantly on acidic organelles such as endosomes and lysosomes. Here we review recent advances in understanding how TPCs are activated by their ligands and identify five salient features: (1) TPCs are Ca2+-permeable non-selective cation channels gated by NAADP. (2) NAADP activation is indirect through associated NAADP receptors. (3) TPCs are also Na+-selective channels gated by PI(3,5)P2. (4) PI(3,5)P2 activation is direct through a structurally-resolved binding site. (5) TPCs switch their ion selectivity in an agonist-dependent manner.
| Type: | Article |
|---|---|
| Title: | Activation of endo-lysosomal two-pore channels by NAADP and PI(3,5)P2. Five things to know |
| Location: | Netherlands |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.ceca.2022.102543 |
| Publisher version: | https://doi.org/10.1016/j.ceca.2022.102543 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Ca2+, Endosomes, JPT2, LSM12, Lysosomes, TPC1, TPC2:TPC3, TPCN1, TPCN2, TPCN3 |
| UCL classification: | UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10145853 |
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