Hartmann, Jonas;
Mayor, Roberto;
(2022)
Self-organized collective cell behaviors as design principles for synthetic developmental biology.
Seminars in Cell & Developmental Biology
10.1016/j.semcdb.2022.04.009.
(In press).
Preview |
Text
Hartmann_Self-organized collective cell behaviors as design principles for synthetic developmental biology_AOP.pdf - Published Version Download (3MB) | Preview |
Abstract
Over the past two decades, molecular cell biology has graduated from a mostly analytic science to one with substantial synthetic capability. This success is built on a deep understanding of the structure and function of biomolecules and molecular mechanisms. For synthetic biology to achieve similar success at the scale of tissues and organs, an equally deep understanding of the principles of development is required. Here, we review some of the central concepts and recent progress in tissue patterning, morphogenesis and collective cell migration and discuss their value for synthetic developmental biology, emphasizing in particular the power of (guided) self-organization and the role of theoretical advances in making developmental insights applicable in synthesis.
| Type: | Article |
|---|---|
| Title: | Self-organized collective cell behaviors as design principles for synthetic developmental biology |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.semcdb.2022.04.009 |
| Publisher version: | https://doi.org/10.1016/j.semcdb.2022.04.009 |
| Language: | English |
| Additional information: | © 2022 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | Biomechanics, Cell sorting, Collective cell migration, Development, Morphogenesis, Neural crest, Patterning, Synthetic Biology |
| UCL classification: | UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10147402 |
Archive Staff Only
 |
View Item |
