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Flexible modulation of sequence generation in the entorhinal–hippocampal system

McNamee, DC; Stachenfeld, KL; Botvinick, MM; Gershman, SJ; (2021) Flexible modulation of sequence generation in the entorhinal–hippocampal system. Nature Neuroscience , 24 (6) pp. 851-862. 10.1038/s41593-021-00831-7. Green open access

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Abstract

Exploration, consolidation and planning depend on the generation of sequential state representations. However, these algorithms require disparate forms of sampling dynamics for optimal performance. We theorize how the brain should adapt internally generated sequences for particular cognitive functions and propose a neural mechanism by which this may be accomplished within the entorhinal–hippocampal circuit. Specifically, we demonstrate that the systematic modulation along the medial entorhinal cortex dorsoventral axis of grid population input into the hippocampus facilitates a flexible generative process that can interpolate between qualitatively distinct regimes of sequential hippocampal reactivations. By relating the emergent hippocampal activity patterns drawn from our model to empirical data, we explain and reconcile a diversity of recently observed, but apparently unrelated, phenomena such as generative cycling, diffusive hippocampal reactivations and jumping trajectory events.

Type: Article
Title: Flexible modulation of sequence generation in the entorhinal–hippocampal system
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/s41593-021-00831-7
Publisher version: https://doi.org/10.1038/s41593-021-00831-7
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Animals, Entorhinal Cortex, Hippocampus, Humans, Nerve Net, Neural Networks, Computer
URI: https://discovery-pp.ucl.ac.uk/id/eprint/10147456
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