Lee, Hyung Chul;
Hastings, Cato;
Oliveira, Nidia MM;
Pérez-Carrasco, Rubén;
Page, Karen M;
Wolpert, Lewis;
Stern, Claudio D;
(2022)
"Neighbourhood watch" model: embryonic epiblast cells assess positional information in relation to their neighbours.
Development
10.1242/dev.200295.
(In press).
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Abstract
In many developing and regenerating systems, tissue pattern is established through gradients of informative morphogens, but we know little about how cells interpret these. Using experimental manipulation of early chick embryos including misexpression of an inducer (VG1 or ACTIVIN) and an inhibitor (BMP4), we test two alternative models for their ability to explain how the site of primitive streak formation is positioned relative to the rest of the embryo. In one model, cells read morphogen concentrations cell-autonomously. In the other, cells sense changes in morphogen status relative to their neighbourhood. We find that only the latter model can account for the experimental results, including some counter-intuitive predictions. This mechanism (which we name “neighbourhood watch” model) illuminates the classic “French Flag Problem” and how positional information is interpreted by a sheet of cells in a large developing system.
| Type: | Article |
|---|---|
| Title: | "Neighbourhood watch" model: embryonic epiblast cells assess positional information in relation to their neighbours |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1242/dev.200295 |
| Publisher version: | https://doi.org/10.1242/dev.200295 |
| Language: | English |
| Additional information: | Copyright © 2022. Published by The Company of Biologists Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. |
| Keywords: | Cell communication, Chick embryo, Gastrulation, Morphogen, Polarity, Primitive streak |
| UCL classification: | UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10147788 |
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