Myers, Patrick O;
Dayan, Victor;
Szeto, Wilson Y;
Thourani, Vinod H;
Malaisrie, S Chris;
Moon, Marc R;
Prager, Richard L;
... Milojevic, Milan; + view all
(2022)
Joint Surgical Associations (EACTS, LACES, ASCVTS, AATS, and STS) Position Statement Regarding the VARC-3 Definitions for Aortic Valve Clinical Research.
European Journal of Cardio-Thoracic Surgery
, 62
(1)
, Article ezac110. 10.1093/ejcts/ezac110.
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Abstract
Conducting optimal clinical research is complex, resource intensive, and time consuming. A critical part of improving the evidence to guide our cardiovascular clinical practice is clinical trials' methodologic design and choices of outcomes and endpoints. The Academic Research Consortia were created to define the most critical and standardized definitions of outcome measures. The Valve Academic Research Consortium (VARC) has substantially improved the quality of trials on aortic valve interventions through its multiple iterations. The latest VARC-3 definitions [1] aim to add more granularity and a patient focus to a rapidly evolving field and are particularly useful in providing a standard definition of bioprosthetic valve failure. This position statement considers the strengths and limitations of the VARC-3 document, identifies areas of concern, and proposes a way forward to further improve these definitions.
| Type: | Article |
|---|---|
| Title: | Joint Surgical Associations (EACTS, LACES, ASCVTS, AATS, and STS) Position Statement Regarding the VARC-3 Definitions for Aortic Valve Clinical Research |
| Location: | Germany |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1093/ejcts/ezac110 |
| Publisher version: | https://doi.org/10.1093/ejcts/ezac110 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology > Comprehensive CTU at UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10148055 |
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