Halls, Daniel;
Leppanen, Jenni;
Kerr-Gaffney, Jess;
Simic, Mima;
Nicholls, Dasha;
Mandy, William;
Williams, Steven;
(2022)
Examining the relationship between autistic spectrum disorder characteristics and structural brain differences seen in anorexia nervosa.
European Eating Disorders Review
10.1002/erv.2910.
(In press).
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Abstract
Cortical differences have been reported in Anorexia Nervosa (AN) compared with healthy controls (HC); however, it is unclear if Autism Spectrum Disorder (ASD) characteristics are related to these cortical differences. The aim of this study was to examine if structural measures were correlated to ASD traits in AN. In total 184 female participants participated in the study; 57 acutely underweight AN participants (AAN), 59 weight-restored participants (WR) and 68 HC. Participants underwent structural magnetic resonance imaging as well as completing the Autism Diagnostic Observation schedule, second edition to examine ASD characteristics. Group differences in curvature, gyrification, surface area, thickness, global grey matter and white matter were measured. Correlation and regression analysis were conducted to examine the relationship between cortical measures and ASD characteristics. Two decreased gyrification clusters in the right post central and supramarginal gyrus and decreased global grey matter were observed in the AAN group compared to HC and WR. No correlations between ASD traits and structural measures existed. Our results suggest structural differences seen in individuals with AN do not appear to be related to ASD characteristics.
| Type: | Article |
|---|---|
| Title: | Examining the relationship between autistic spectrum disorder characteristics and structural brain differences seen in anorexia nervosa |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/erv.2910 |
| Publisher version: | https://doi.org/10.1002/erv.2910 |
| Language: | English |
| Additional information: | © 2022 The Authors. European Eating Disorders Review published by Eating Disorders Association and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | Anorexia nervosa, autism spectrum disorder, gyrification, structural MRI, surfaced-based morphometry |
| UCL classification: | UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Clinical, Edu and Hlth Psychology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10148836 |
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