Tayoun, AA;
Loney, T;
Khansaheb, H;
Ramaswamy, S;
Harilal, D;
Deesi, ZO;
Varghese, RM;
... Alsheikh-Ali, A; + view all
(2020)
Multiple early introductions of SARS-CoV-2 into a global travel hub in the Middle East.
Scientific Reports
, 10
, Article 17720. 10.1038/s41598-020-74666-w.
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Abstract
International travel played a significant role in the early global spread of SARS-CoV-2. Understanding transmission patterns from different regions of the world will further inform global dynamics of the pandemic. Using data from Dubai in the United Arab Emirates (UAE), a major international travel hub in the Middle East, we establish SARS-CoV-2 full genome sequences from the index and early COVID-19 patients in the UAE. The genome sequences are analysed in the context of virus introductions, chain of transmissions, and possible links to earlier strains from other regions of the world. Phylogenetic analysis showed multiple spatiotemporal introductions of SARS-CoV-2 into the UAE from Asia, Europe, and the Middle East during the early phase of the pandemic. We also provide evidence for early community-based transmission and catalogue new mutations in SARS-CoV-2 strains in the UAE. Our findings contribute to the understanding of the global transmission network of SARS-CoV-2.
| Type: | Article |
|---|---|
| Title: | Multiple early introductions of SARS-CoV-2 into a global travel hub in the Middle East |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/s41598-020-74666-w |
| Publisher version: | https://doi.org/10.1038/s41598-020-74666-w |
| Language: | English |
| Additional information: | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
| Keywords: | Adult, Aged, Asia, Betacoronavirus, COVID-19, Child, Child, Preschool, Coronavirus Infections, Europe, Female, Humans, Male, Middle Aged, Mutation, Pandemics, Phylogeny, Pneumonia, Viral, SARS-CoV-2, Spatio-Temporal Analysis, Travel, United Arab Emirates, Whole Genome Sequencing, Young Adult |
| UCL classification: | UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10148949 |
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