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Nanomedicine: controlling nanoparticle clearance for translational success

Zhu, Geyunjian Harry; Gray, Alex BC; Patra, Hirak K; (2022) Nanomedicine: controlling nanoparticle clearance for translational success. Trends in Pharmacological Sciences 10.1016/j.tips.2022.05.001. (In press). Green open access

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Abstract

Achieving complete nanoparticle (NP) clearance is a key consideration in the design of safe and translatable nanomedicines. Renal-clearable nano formulations must encompass the beneficial nanoscale functionalities whilst exhibiting clearance profiles like those of small-molecule therapeutics. Recent developments in the field have enabled the growth of novel renal-clearable NPs with transformable sizes that take advantage of alternative clearance mechanisms to achieve controlled and efficient renal excretion to improve potential clinical translation.

Type: Article
Title: Nanomedicine: controlling nanoparticle clearance for translational success
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.tips.2022.05.001
Publisher version: https://doi.org/10.1016/j.tips.2022.05.001
Language: English
Additional information: © 2022 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons. org/licenses/by/4.0/).
Keywords: body clearance, nanoparticle, renal clearance
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Surgical Biotechnology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
URI: https://discovery-pp.ucl.ac.uk/id/eprint/10150561
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