Karvandi, Elika;
Hanrahan, John Gerrard;
Khan, Danyal Zaman;
Boloux, Pierre-Marc;
Bremner, Fion;
Cabrilo, Ivan;
Dorward, Neil;
... Marcus, Hani Joseph; + view all
(2022)
A patient-reported outcome measure for patients with pituitary adenoma undergoing transsphenoidal surgery.
Pituitary
10.1007/s11102-022-01251-x.
(In press).
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Abstract
PURPOSE: Pituitary adenomas affect patients’ quality-of-life (QoL) across several domains, with long-term implications even following gross-total resection or disease remission. While clinical outcomes can assess treatment efficacy, they do not capture variations in QoL. We present the development and validation of a patient reported outcome measure (PROM) for patients with pituitary adenomas undergoing transsphenoidal surgery. METHODS: The COSMIN checklist informed the development of the pituitary outcome score (POS). Consecutive patients undergoing surgical treatment for suspected pituitary adenoma at a single centre were included prospectively. An expert focus group and patient interviews informed item generation. Item reduction was conducted through exploratory factor analysis and expert consensus, followed by assessment of the tool’s validity, reliability, responsiveness, and interpretability. RESULTS: 96 patients with a median age of 50 years validated the POS. The final questionnaire included 25 questions with four subscales: EQ-5D-5L-QoL, Visual Symptoms, Endocrine Symptoms and Nasal Symptoms. CONCLUSION: The POS is the first validated PROM for patients undergoing transsphenoidal surgery for a pituitary adenoma. This PROM could be integrated into contemporary practice to provide patient-centred outcomes assessment for this patient group, aligning more closely with patient objectives.
| Type: | Article |
|---|---|
| Title: | A patient-reported outcome measure for patients with pituitary adenoma undergoing transsphenoidal surgery |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1007/s11102-022-01251-x |
| Publisher version: | https://doi.org/10.1007/s11102-022-01251-x |
| Language: | English |
| Additional information: | © 2022 Springer Nature Switzerland AG. This article is licensed under a Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | Pituitary adenoma, Patient-reported outcome measure, PROM, Transsphenoidal surgery, Quality of life, Pituitary surgery |
| UCL classification: | UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10152171 |
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