Chen, Kezhong;
Yang, Airong;
Carbone, David P;
Kanu, Nnennaya;
Liu, Ke;
Wang, Ruiru;
Nie, Yuntao;
... Wang, Jun; + view all
(2022)
Spatiotemporal genomic analysis reveals distinct molecular features in recurrent stage I non-small cell lung cancers.
Cell Reports
, 40
(2)
, Article 111047. 10.1016/j.celrep.2022.111047.
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Abstract
Stage I non-small cell lung cancer (NSCLC) presents diverse outcomes. To identify molecular features leading to tumor recurrence in early-stage NSCLC, we perform multiregional whole-exome sequencing (WES), RNA sequencing, and plasma-targeted circulating tumor DNA (ctDNA) detection analysis between recurrent and recurrent-free stage I NSCLC patients (CHN-P cohort) who had undergone R0 resection with a median 5-year follow-up time. Integrated analysis indicates that the multidimensional clinical and genomic model can stratify the prognosis of stage I NSCLC in both CHN-P and EUR-T cohorts and correlates with positive pre-surgical deep next generation sequencing (NGS) ctDNA detection. Increased genomic instability related to DNA interstrand crosslinks and double-strand break repair processes is significantly associated with early tumor relapse. This study reveals important molecular insights into stage I NSCLC and may inform clinical postoperative treatment and follow-up strategies.
| Type: | Article |
|---|---|
| Title: | Spatiotemporal genomic analysis reveals distinct molecular features in recurrent stage I non-small cell lung cancers |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.celrep.2022.111047 |
| Publisher version: | https://doi.org/10.1016/j.celrep.2022.111047 |
| Language: | English |
| Additional information: | © 2022 The Authors. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| Keywords: | Non-small cell lung cancer, heterogeneity, multiregion, genomic, early stage, surgery, disease-free survival, circulating tumor DNA, genome instability, DNA damage repair |
| UCL classification: | UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10152423 |
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