Mellor, Ryan D;
Uchegbu, Ijeoma F;
(2022)
Ultrasmall-in-Nano: Why Size Matters.
Nanomaterials
, 12
(14)
p. 2476.
10.3390/nano12142476.
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Abstract
Gold nanoparticles (AuNPs) are continuing to gain popularity in the field of nanotechnology. New methods are continuously being developed to tune the particles’ physicochemical properties, resulting in control over their biological fate and applicability to in vivo diagnostics and therapy. This review focuses on the effects of varying particle size on optical properties, opsonization, cellular internalization, renal clearance, biodistribution, tumor accumulation, and toxicity. We review the common methods of synthesizing ultrasmall AuNPs, as well as the emerging constructs termed ultrasmall-in-nano—an approach which promises to provide the desirable properties from both ends of the AuNP size range. We review the various applications and outcomes of ultrasmall-in-nano constructs in vitro and in vivo.
| Type: | Article |
|---|---|
| Title: | Ultrasmall-in-Nano: Why Size Matters |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3390/nano12142476 |
| Publisher version: | https://doi.org/10.3390/nano12142476 |
| Language: | English |
| Additional information: | This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | ultrasmall-in-nano; gold nanoparticles; clearance; biodistribution; tumor accumulation; toxicity |
| UCL classification: | UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10152654 |
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