Fu, Tian;
Chen, Hui;
Chen, Xuejie;
Sun, Yuhao;
Xie, Ying;
Deng, Minzi;
Hesketh, Therese;
... Chen, Jie; + view all
(2022)
Sugar-sweetened beverages, artificially sweetened beverages and natural juices and risk of inflammatory bowel disease: a cohort study of 121,490 participants.
Alimentary Pharmacology and Therapeutics
10.1111/apt.17149.
(In press).
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Abstract
Background: Inflammatory bowel diseases (IBD) have been related to high-sugar dietary patterns, but the associations of different types of beverages with IBD risk are largely unknown. Aims: To examine the associations of intake of sugar-sweetened beverages, artificially sweetened beverages and natural juices with IBD risk. Methods: This cohort study included 121,490 participants in the UK Biobank who were free of IBD at recruitment. Intake of beverages was obtained from repeated 24-h diet recalls in 2009–2012. Cox proportional hazard models were used to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs) for associations of beverage intake with IBD risk. Results: During a mean (standard deviation) follow-up of 10.2 (1.5) years, we documented 510 incident IBD cases, (143 Crohn's disease (CD) and 367 ulcerative colitis (UC)). Compared to non-consumers, participants consuming >1 unit per day of sugar-sweetened beverages were at significantly higher risk of IBD (HR 1.51, 95% CI 1.11–2.05), but the trend was non-significant (p-trend = 0.170). This association was significant for CD (HR 2.05, 95% CI 1.22–3.46), but not for UC (HR 1.31, 95% CI 0.89–1.92). We did not observe significant associations for the consumption of artificially sweetened beverages or natural juices. Conclusions: Our findings suggest an association between consumption of sugar-sweetened beverages, rather than artificially sweetened beverages or natural juices, and IBD risk.
| Type: | Article |
|---|---|
| Title: | Sugar-sweetened beverages, artificially sweetened beverages and natural juices and risk of inflammatory bowel disease: a cohort study of 121,490 participants |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/apt.17149 |
| Publisher version: | https://doi.org/10.1111/apt.17149 |
| Language: | English |
| Additional information: | © 2022 The Authors. Alimentary Pharmacology & Therapeutics published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Gastroenterology & Hepatology, Pharmacology & Pharmacy, CARDIOVASCULAR-DISEASE, RECOVERY BIOMARKERS, 5 VALIDATION, UK BIOBANK, CONSUMPTION, ASSOCIATION, PATTERNS, PROTEIN, OBESITY |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10153080 |
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