Hoffmann-Vold, AM;
Distler, O;
Bruni, C;
Denton, CP;
de Vries-Bouwstra, J;
Matucci Cerinic, M;
Vonk, MC;
(2022)
Systemic sclerosis in the time of COVID-19.
The Lancet Rheumatology
, 4
(8)
e566-e575.
10.1016/S2665-9913(22)00130-8.
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Abstract
The COVID-19 pandemic represents one of the biggest challenges of the 21st century. In addition to the general effect on society and health-care systems, patients with systemic sclerosis and their physicians face specific challenges related to the chronic nature of their disease, the involvement of multiple organs, and the use of immunosuppressive treatments. Data from registries and single centre cohorts indicate that the risk of contracting SARS-CoV-2 does not seem to increase substantially in people with systemic sclerosis; conversely, severe COVID-19 outcomes are seen more frequently in these patients than in the general population. Vaccination against SARS-CoV-2 is therefore highly recommended for patients with systemic sclerosis; however, no specific recommendations are available regarding the different vaccine platforms. Both patients and physicians should be aware that the effectiveness of vaccines might be reduced in patients taking immunosuppressive therapy, because antibody responses might be blunted, specifically in patients treated with rituximab and mycophenolate mofetil.
| Type: | Article |
|---|---|
| Title: | Systemic sclerosis in the time of COVID-19 |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/S2665-9913(22)00130-8 |
| Publisher version: | https://doi.org/10.1016/S2665-9913(22)00130-8 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions. |
| UCL classification: | UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10153285 |
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