Boles, Jessica E;
Bennett, Charlotte;
Baker, Jennifer;
Hilton, Kira LF;
Kotak, Hiral A;
Clark, Ewan R;
Long, Yifan;
... Hiscock, Jennifer R; + view all
(2022)
Establishing the selective phospholipid membrane coordination, permeation and lysis properties for a series of 'druggable' supramolecular self-associating antimicrobial amphiphiles.
Chemical Science
, 2022
(13)
pp. 9761-9773.
10.1039/d2sc02630a.
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Abstract
A combination of computational and synthetic phospholipid vesicle/nanodisc assays are used to investigate the mode of action for a class of antimicrobial agents, while a range of DMPK studies establish agent druggability.
| Type: | Article |
|---|---|
| Title: | Establishing the selective phospholipid membrane coordination, permeation and lysis properties for a series of 'druggable' supramolecular self-associating antimicrobial amphiphiles |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1039/d2sc02630a |
| Language: | English |
| Additional information: | This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. See: https://creativecommons.org/licenses/by/3.0/ |
| Keywords: | Science & Technology, Physical Sciences, Chemistry, Multidisciplinary, Chemistry, DISCOVERY, ENHANCERS, BILAYER, SSAS |
| UCL classification: | UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry UCL > Provost and Vice Provost Offices > UCL BEAMS UCL |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10154238 |
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