Tirole, Margot;
Huelin Gorriz, Marta;
Takigawa, Masahiro;
Kukovska, Lilia;
Bendor, Daniel;
(2022)
Experience-driven rate modulation is reinstated during hippocampal replay.
eLife
, 11
, Article e79031. 10.7554/eLife.79031.
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Abstract
Replay, the sequential reactivation within a neuronal ensemble, is a central hippocampal mechanism postulated to drive memory processing. While both rate and place representations are used by hippocampal place cells to encode behavioral episodes, replay has been largely defined by only the latter - based on the fidelity of sequential activity across neighboring place fields. Here we show that dorsal CA1 place cells in rats can modulate their firing rate between replay events of two different contexts. This experience-dependent phenomenon mirrors the same pattern of rate modulation observed during behavior and can be used independently from place information within replay sequences to discriminate between contexts. Our results reveal the existence of two complementary neural representations available for memory processes.
| Type: | Article |
|---|---|
| Title: | Experience-driven rate modulation is reinstated during hippocampal replay |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.7554/eLife.79031 |
| Publisher version: | https://doi.org/10.7554/eLife.79031 |
| Language: | English |
| Additional information: | Copyright © 2022, Tirole et al. This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) permitting unrestricted use and redistribution provided that the original author and source are credited. |
| Keywords: | Hippocampus, sleep, replay, memory consolidation |
| UCL classification: | UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Experimental Psychology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10154768 |
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