Rodríguez-Pombo, Lucía;
Awad, Atheer;
Basit, Abdul W;
Alvarez-Lorenzo, Carmen;
Goyanes, Alvaro;
(2022)
Innovations in Chewable Formulations: The Novelty and Applications of 3D Printing in Drug Product Design.
Pharmaceutics
, 14
(8)
, Article 1732. 10.3390/pharmaceutics14081732.
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Abstract
Since their introduction, chewable dosage forms have gained traction due to their ability to facilitate swallowing, especially in paediatric, geriatric and dysphagia patients. Their benefits stretch beyond human use to also include veterinary applications, improving administration and palatability in different animal species. Despite their advantages, current chewable formulations do not account for individualised dosing and palatability preferences. In light of this, three-dimensional (3D) printing, and in particular the semi-solid extrusion technology, has been suggested as a novel manufacturing method for producing customised chewable dosage forms. This advanced approach offers flexibility for selecting patient-specific doses, excipients, and organoleptic properties, which are critical for ensuring efficacy, safety and adherence to the treatment. This review provides an overview of the latest advancements in chewable dosage forms for human and veterinary use, highlighting the motivations behind their use and covering formulation considerations, as well as regulatory aspects.
| Type: | Article |
|---|---|
| Title: | Innovations in Chewable Formulations: The Novelty and Applications of 3D Printing in Drug Product Design |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3390/pharmaceutics14081732 |
| Publisher version: | https://doi.org/10.3390/pharmaceutics14081732 |
| Language: | English |
| Additional information: | : © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). |
| Keywords: | 3D printed medicines and pharmaceuticals; orally disintegrating formulations; human and veterinary medicine; precision medicine; taste masking; digital healthcare; chewable oral formulations; patient acceptability and palatability; orodispersible tablets and films |
| UCL classification: | UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10154787 |
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