Coerver, Eline ME;
Strijbis, Eva MM;
Petzold, Laura F;
Van Kempen, Zoe LE;
Jasperse, Bas;
Barkhof, Frederik;
Oudejans, Cees BM;
... Killestein, Joep; + view all
(2022)
The association between blood MxA mRNA and long-term disease activity in early multiple sclerosis.
Frontiers in Neurology
, 13
, Article 907245. 10.3389/fneur.2022.907245.
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Abstract
Background: Myxovirus resistance protein A (MxA) is a protein that is upregulated by interferon-beta. Homeostatic MxA mRNA levels are potentially correlated with inflammatory disease activity in multiple sclerosis (MS) and could have an important role in MS pathology. Aim: To investigate the association between myxovirus resistance protein A (MxA) mRNA levels in blood and disease activity and progression in MS over a long-term follow-up period. Methods: Baseline blood MxA mRNA levels were determined in a prospective cohort of 116 untreated patients with a clinically isolated syndrome (CIS) or early relapsing remitting MS (RRMS), and related to long-term relapses, radiological disease activity, clinical scores [Expanded Disability Status Scale (EDSS), timed-25-foot walk (T25FW), 9-hole-peg test (9HPT)], MS type, and disease modifying therapy (DMT) use. Results: Low MxA mRNA levels were associated with the occurrence of ≥9 T2-lesions on MRI imaging and the occurrence of relapses during long-term follow-up (median 11 years, IQR 5.91-13.69 years). MxA mRNA levels were not associated with EDSS, T25FW, 9HPT, and MS subtype. Conclusion: Baseline MxA mRNA levels are associated with long-term development of T2-lesions on MRI-scans in our cohort. This confirms the relevance of the endogenous interferon-beta system in the occurrence of MS disease activity.
| Type: | Article |
|---|---|
| Title: | The association between blood MxA mRNA and long-term disease activity in early multiple sclerosis |
| Location: | Switzerland |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3389/fneur.2022.907245 |
| Publisher version: | https://doi.org/10.3389/fneur.2022.907245 |
| Language: | English |
| Additional information: | © 2022 Coerver, Strijbis, Petzold, Van Kempen, Jasperse, Barkhof, Oudejans, Uitdehaag, Teunissen and Killestein. This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | demyelinating disease, multiple sclerosis, MRI, myxovirus resistance protein A (MxA), mRNA |
| UCL classification: | UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Brain Repair and Rehabilitation UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10155888 |
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