Li, K;
Yatsunyk, LA;
Neidle, S;
(2022)
Machine learning shows torsion angle preferences in left-handed and right-handed quadruplex DNAs.
Biophysical Journal
10.1016/j.bpj.2022.08.021.
(In press).
Preview |
Text
1-s2.0-S0006349522006816-main.pdf - Published Version Download (828kB) | Preview |
Abstract
Left-handed G quadruplexes (LHG4) have been recently discovered as a new class of G quadruplexes. The biological functions of LHG4s are still unknown, but they share a striking resemblance to Z-DNA in their helicity and jagged phosphate backbone. To further understand structural features of the LHG4s that define their left handedness, we have employed human-interpretable machine-learning methods to classify right- and left-handed G4s purely based on torsional angle analysis. Our results reveal the importance of the α, β, δ, and χ angles in left-handed structuring across both Z-DNAs and LHG4s. Our analysis may serve as the first step to understanding the conditions of formation for LHG4s and their potential biological relevance.
| Type: | Article |
|---|---|
| Title: | Machine learning shows torsion angle preferences in left-handed and right-handed quadruplex DNAs |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.bpj.2022.08.021 |
| Publisher version: | https://doi.org/10.1016/j.bpj.2022.08.021 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third-party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| UCL classification: | UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10156470 |
Archive Staff Only
 |
View Item |
