Miller, Natalie Ella;
Lacey, Rebecca E;
(2022)
Childhood adversity and cardiometabolic biomarkers in mid-adulthood in the 1958 British birth cohort.
SSM - Population Health
, 19
, Article 101260. 10.1016/j.ssmph.2022.101260.
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Abstract
Studies that have examined associations between adverse childhood experiences (ACEs) and cardiometabolic biomarkers in adulthood are limited as they mainly focus on childhood maltreatment. This study aimed to examine the association between a range of prospectively and retrospectively reported ACEs and cardiometabolic biomarkers in mid-adulthood. Multiply-imputed data on 8511 participants from the National Child Development Study (1958 British birth cohort) were used. ACEs were prospectively reported at ages 7, 11 and 16, and retrospectively reported at age 33/44/45. Cardiometabolic outcomes assessed at age 44/45 included glycated haemoglobin (HbA1c), cholesterol (total, low- and high-density lipoprotein), triglycerides, blood pressure (systolic and diastolic), body mass index, waist circumference and metabolic syndrome. Parental separation/divorce, physical neglect, emotional neglect and psychological abuse were associated with lower HDL cholesterol. Parental offending and physical neglect were associated with higher triglyceride concentrations. Parental offending was also associated with increased HbA1c. Exposure to 2+ (vs. 0) prospective ACEs was associated with lower HDL cholesterol. All these associations were after adjustment for sex and multiple early life factors. To conclude, several individual ACEs are associated with poorer cardiometabolic risk factor profiles in mid-adulthood. Furthermore, exposure to two or more prospective ACEs is associated with lower HDL cholesterol concentrations in mid-adulthood.
| Type: | Article |
|---|---|
| Title: | Childhood adversity and cardiometabolic biomarkers in mid-adulthood in the 1958 British birth cohort |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.ssmph.2022.101260 |
| Publisher version: | https://doi.org/10.1016/j.ssmph.2022.101260 |
| Language: | English |
| Additional information: | Copyright © 2022 The Authors. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | Childhood adversity, Cohort, Cardiovascular disease, Cardiometabolic risk |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10156891 |
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