Schön, C;
Mödinger, Y;
Krüger, F;
Doebis, C;
Pischel, I;
Bonnländer, B;
(2021)
A new high-quality elderberry plant extract exerts antiviral and immunomodulatory effects in vitro and ex vivo.
Food and Agricultural Immunology
, 32
(1)
pp. 650-662.
10.1080/09540105.2021.1978941.
Preview |
PDF
A new high.pdf - Published Version Download (2MB) | Preview |
Abstract
Infections of the respiratory system, including common cold and influenza, are affecting people worldwide and are more or less prone to spread depending on the season and viral load of the host. For reducing symptoms and duration of illness, treatment options to standard prescribed drugs are in demand. Natural products could provide immune-supporting treatment alternatives. Elderberry extracts have been used in traditional medicine for the treatment of respiratory infections for decades and numerous studies describe the beneficial effects of elderberries on the immune system and respiratory infectious disease. We investigated the immunomodulative and antiviral effects of a high-quality, anthocyanin-enriched elderberry fruit extract (eldosamb®). Results reveal that elderberry extract reduced the secretion of pro-inflammatory cytokines TNF-α and IFN-γ, leading to a shift towards the Th2-Helper cell response and showing antiviral efficacy against the MVA virus. Thus, with its anti-inflammatory and antiviral bioactivity the proprietary elderberry extract suggests its use as an immunomodulatory health product.
| Type: | Article |
|---|---|
| Title: | A new high-quality elderberry plant extract exerts antiviral and immunomodulatory effects in vitro and ex vivo |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1080/09540105.2021.1978941 |
| Publisher version: | https://doi.org/10.1080/09540105.2021.1978941 |
| Language: | English |
| Additional information: | © 2021 The Author(s). Published with license by Taylor and Francis Group, LLC This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way. |
| Keywords: | Elderberry (Sambucus nigraL.) extract; TNF-α; inflammation; T-cell activation; modified vaccinia virus Ankara; IL-10 |
| UCL classification: | UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10156963 |
Archive Staff Only
 |
View Item |
