Patel, Sandip;
Zissimopoulos, Spyros;
Marchant, Jonathan S;
(2022)
Endo-Lysosomal Two-Pore Channels and Their Protein Partners.
Handbook of Experimental Pharmacology
, 278
pp. 199-214.
10.1007/164_2022_601.
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Abstract
Two-pore channels are ion channels expressed on acidic organelles such as the various vesicles that constitute the endo-lysosomal system. They are permeable to Ca^{2+} and Na^{+} and activated by the second messenger NAADP as well as the phosphoinositide, PI(3,5)P_{2} and/or voltage. Here, we review the proteins that interact with these channels including recently identified NAADP receptors.
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