Li, Zonglun;
Tsybina, Yuliya;
Gordleeva, Susanna;
Zaikin, Alexey;
(2022)
Impact of Astrocytic Coverage of Synapses on the Short-Term Memory of a Computational Neuron-Astrocyte Network.
Mathematics
, 10
(18)
, Article 3275. 10.3390/math10183275.
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Abstract
Working memory refers to the capability of the nervous system to selectively retain short-term memories in an active state. The long-standing viewpoint is that neurons play an indispensable role and working memory is encoded by synaptic plasticity. Furthermore, some recent studies have shown that calcium signaling assists the memory processes and the working memory might be affected by the astrocyte density. Over the last few decades, growing evidence has also revealed that astrocytes exhibit diverse coverage of synapses which are considered to participate in neuronal activities. However, very little effort has yet been made to attempt to shed light on the potential correlations between these observations. Hence, in this article, we leverage a computational neuron–astrocyte model to study the short-term memory performance subject to various astrocytic coverage and we demonstrate that the short-term memory is susceptible to this factor. Our model may also provide plausible hypotheses for the various sizes of calcium events as they are reckoned to be correlated with the astrocytic coverage.
| Type: | Article |
|---|---|
| Title: | Impact of Astrocytic Coverage of Synapses on the Short-Term Memory of a Computational Neuron-Astrocyte Network |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3390/math10183275 |
| Publisher version: | https://doi.org/10.3390/math10183275 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third-party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| Keywords: | Science & Technology, Physical Sciences, Mathematics, neuron, astrocyte, network, short-term memory, spatial frequency, computational biology, SYNAPTIC-TRANSMISSION, WORKING-MEMORY, CALCIUM, SYNCHRONIZATION, MODULATION, GLUTAMATE, DYNAMICS, HEALTH, GLIA, GLIOTRANSMISSION |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Womens Cancer UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10157275 |
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